David Orange, NARCOMS Staff Writer with contributions from John Brockington, MD, Associate Professor and Director, Division of General Neurology at the University of Alabama at… »
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Modulation of Inflammatory Response in Multiple Sclerosis by Altered Peptide Ligand (APL)
Silva Markovic-Plese, MD—Department of Neurology, University of North Carolina at Chapel Hill, North Carolina School of Medicine, North Carolina Introduction The recent expansion in our understanding of the development of the disease in patients with multiple sclerosis (MS) has allowed therapies to be designed with ever-greater specificity. Some of these medications are even able to… »
Modulation of Inflammatory Response in Multiple Sclerosis by Altered Peptide Ligand (APL)
Silva Markovic-Plese, MD—Department of Neurology, University of North Carolina at Chapel Hill, North Carolina School of Medicine, North Carolina Introduction The recent expansion in our understanding of the development of the disease in patients with multiple sclerosis (MS) has allowed therapies to be designed with ever-greater specificity. Some of these medications are even able to… »
Disability as a Function of Disease Duration
Tuula Tyry, PhD, MAED, Program Manager, NARCOMS Project— Barrow Neurological Institute, St. Joseph’s Hospital, Phoenix, AZ Introduction The NARCOMS MS Patient Registry continues to grow and, as of June 2004, has over 24,000 active participants. Online participation has climbed to 66%, which is a much appreciated and cost-saving trend that we hope will continue. In… »
Mitoxantrone: An Effective Drug for Secondary and Relapsing Progressive Forms of Multiple Sclerosis
Craig H. Smith, MD, MS Hub Medical Group, Seattle, WA Multiple sclerosis (MS) has not been cured, but in recent years several medications have become available that can slow its progression. Even so, many patients eventually enter a stage of progressive deterioration that has been very difficult to treat. Two years ago the Food and… »
Bladder Symptoms Among Registry Participants
Olympia Hadjimichael, MPH, Coordinator , NARCOMS Project, Yale Center for Multiple Sclerosis Treatment and Research , Yale University School of Medicine and VA Connecticut Healthcare System , West Haven , CT Bladder symptoms are very common among people with multiple sclerosis (MS), because MS can affect the nerves responsible for urinary control. In the previous… »
Infections and Vaccinations in MS: Causative Roles?
Expert Consultant Andrew D. Goodman, MD, Department of Neurology, University of Rochester Medical Center, Rochester, NY Progress to Date Since multiple sclerosis (MS) lesions seem to be caused by immune attacks, one likely explanation for MS is that it is an autoimmune disease; that is, a disease in which the immune system incorrectly identifies one… »
Disease Status and Health Care Delivery for Veterans and Non-Veterans With MS
Timothy L. Vollmer, MD, Director, Yale Center for Multiple Sclerosis Treatment and Research, Yale University School of Medicine, VA Connecticut Healthcare System, New Haven, CT; Olympia Hadjimichael, MPH, Coordinator, NARCOMS Project, Yale Center for Multiple Sclerosis Treatment and Research, Yale University School of Medicine, VA Connecticut Healthcare System, New Haven, CT Multiple sclerosis (MS) is… »
Urinary Tract Infections (UTIs) and Multiple Sclerosis: Connection Between UTIs and Neurological Progression?
Expert Consultant Harris E. Foster, Jr., MD, Associate Professor of Surgery (Urology), Yale University School of Medicine, New Haven, CT Progress to Date Bladder problems are common in people with multiple sclerosis (MS), affecting up to 90% to 100% of patients during the course of their disease (Foster, 2002). Patients may have trouble with holding… »
Bladder Symptoms and Multiple Sclerosis
Harris E. Foster, Jr., MD, Associate Professor of Surgery (Urology), Yale University School of Medicine, New Haven, CT Progress to Date As the ads for adult urinary pads discretely imply, bladder control problems are uncomfortable and potentially embarrassing, unfortunately, bladder symptoms are very common in patients with multiple sclerosis (MS). Up to 80% of patients… »
Spasticity in Multiple Sclerosis
Randall T. Shapiro, MD, Director, Fairview Multiple Sclerosis Center, Minneapolis, MN Progress to Date For patients with multiple sclerosis (MS), fatigue and muscle weakness can make it difficult just to get out of bed. The increased immobility and pain of spasticity can make performing daily tasks even harder. Spasticity is a condition in which a… »
Driving with Multiple Sclerosis: Can I? Should I?
Osteoporosis and Physical Activity Among NARCOMS Participants