A Multiple Sclerosis clinical trial is now open for enrollment. It is a phase II study aimed at the treatment of poor prognosis Multiple Sclerosis.

Location: All North American clinical trial sites originally involved in the study.
Purpose: To determine the long-term effects of Betaseron on multiple sclerosis in comparison to patients who did not get Betaseron.

A 24-week, Randomized, Double Blind, Parallel-Group, Placebo-Controlled, Dose-Finding, Safety, Tolerability and Efficacy Study of the Human Anti-IL-12 Antibody ABT-874 in Subjects With Multiple Sclerosis with a 24- week Double Blind Active Extension Phase

Neurocrine Biosciences, Inc. is seeking up to 150 eligible patients at approximately 25 centers in North America to participate in a study to evaluate the safety, effectiveness and tolerability of a new study drug to treat relapsing forms of MS.

Location: Multi-centers throughout the US and Canada
Purpose: A phase IV study to compare the total number of relapses experienced by patients randomized to maintain treatment on high dose INF therapy compared to those who were transferred to Copaxone® (glatiramer acetate) in patients with relapsing multiple sclerosis.

Location: University Hospital and Medical Center, Stony Brook, NY; Rochester, NY; Buffalo, NY; Rhode Island
Purpose: This study will examine the effectiveness of the drug donepezil and of sugar water for enhancing memory in individuals with MS. Donepezil (also known as Aricept®) has been FDA approved for improving memory and learning in individuals with Alzheimer’s disease.

Location: Four centers in the US and Canada
Purpose: To assess the safety of BHT-3009 alone or combined with atorvastatin (Lipitor®) in patients with multiple sclerosis (MS), and to determine the effect of treatment on immune response.

Location: Multi-centers in the US
Purpose: This study will test the safety and efficacy of an investigational medication in the treatment of patients with MS suffering from pseudobulbar affect (a condition characterized by frequent episodes of uncontrollable laughing and crying that are out of proportion with the underlying emotion; also called excessive emotionalism or emotional lability).

Location: Multi-centers in the US
Purpose: The primary objective of the study is to assess the clinical efficacy of Rebif 44 mcg three times per week compared with Copaxone 20 mg daily in patients with relapsing MS.

Location: Hospital of the University of Pennsylvania, Philadelphia, PA
Purpose: The purpose of this study is to determine whether raising low levels of the natural antioxidant uric acid by the administration of a precursor, inosine, has any therapeutic effect on the progression of RRMS and secondary progressive MS.

Location: Brigham and Women’s Hospital/Harvard Medical School, Boston, MA
Purpose: To determine the effects of Copaxone alone compared to Copaxone plus albuterol in persons with MS.

Location: National study sponsored by the National Institute of Neurological Disorders and Stroke (NINDS), based in Bethesda, MD
Purpose: To examine the safety and effectiveness of Zenapax (a laboratorymanufactured antibody) in treating MS.

Location: Phoenix, AZ
Purpose: To determine how immune responses change over time after glatiramer acetate (Copaxone) treatment has been terminated.

Location: National study sponsored by the National Institute of Neurological Disorders and Stroke (NINDS), based in Bethesda, MD
Purpose: Developing a better understanding of the cause of MS.

Location: VA Medical Center, Portland, OR
Purpose:
• To evaluate the possibility that MS is a risk factor for hearing impairment, tinnitus, and central auditory dysfunction
• To determine the nature and extent of auditory dysfunction in persons with MS compared to those without MS, and determine neuropsychological function in each group
• To evaluate the extent to [...]

Location: Warren Grant Magnuson Clinical Center at the National Institutes of Health, Bethesda, MD.
Purpose: To evaluate normal volunteers and patients with a variety of diseases with MRI. Researchers will attempt different MRI methods and techniques as well as different levels of magnetic strength. MRI and MRS do not use ionizing radiation.

Location: Warren Grant Magnuson Clinical Center at the National Institutes of Health, Bethesda, MD.
Purpose: To determine the cause(s) of persistent signs and symptoms of Lyme disease despite taking what is currently considered to be adequate antibiotic therapy; and to assemble a well characterized cohort of patients with presumed chronic Lyme disease as well as relevant [...]

Most persons who receive this publication (MSQR) are already enrolled in the surveybased NARCOMS MS Patient Registry Long- Term Study (especially if there is a number immediately above your name on the address label). However, if you know other persons with MS in the US who might like to participate, we would be pleased to [...]

Specimen Collection and Archiving for Immunological Investigations Aiming to Understand the Immunological Mechanism of MS and Identify New Targets for Immune Therapies for MS and Other Neuroinflammatory Disorders
Location: Phoenix, AZ
Purpose: To understand the immunological mechanism of multiple sclerosis (MS) and identify new targets for immune therapies for MS and other necroinflammatory disorders.

Location: Warren G. Magnuson Clinical Center, 9000 Rockville Pike, Bethesda, MD
Purpose: The purpose of this study is to examine tongue strength and endurance, how the tongue applies pressure during swallowing, and how the chin muscles react during swallowing in healthy volunteers and in patients with dysphagia (difficulty swallowing).